Further Biologically Active Derivatives of 1, 3-Diketones

Abstract

Abstract
This study presents the synthesis and characterisation of new compounds of antimicrobial activity by the coupling of aromatic aldehydes with 5,5-dimethylcyclohexan-1,3-dione (dimedone). The products were refluxed with Nbenzyl-N-phenylhydrazine in acetic acid. With the help of micro- and IR-spectral analysis, the molecular structures of the synthesised products were determined. These were ascertained using H NMR at 60MHz and TMS as internal standard. Biological activity of the derivatives against gram-positive Cocci and Bacilli as well as gram-negative Bacilli was tested and found to vary widely from inactive to highly active, which could prove to be of practical pharmaceutical application.