Opportunistic infections

Investigating Metabolic and Molecular Ecological Evolution of Opportunistic Pulmonary Fungal Coinfections: Protocol for a Laboratory-Based Cross-Sectional Study

Background: Fungal-bacterial cocolonization and coinfections pose an emerging challenge among patients suspected of having pulmonary tuberculosis (PTB); however, the underlying pathogenic mechanisms and microbiome interactions are poorly understood. Understanding how environmental microbes, such as fungi and bacteria, coevolve and develop traits to evade host immune responses and resist treatment is critical to controlling opportunistic pulmonary fungal coinfections. In this project, we propose to study the coexistence of fungal and bacterial...

Frequency of fungal pathogens in autopsy studies of people who died with HIV in Africa: a scoping review

Background: Fungal infections are common in HIV-infected individuals and significantly contribute to mortality. However, a substantial number of cases are undiagnosed before death. Objective: To determine the frequency of fungal pathogens in autopsy studies of people who died with HIV in Africa. Methods: We conducted a scoping review of autopsy studies conducted in Africa. Data sources: PubMed, Scopus, Web of Science, Embase, Google Scholar, and African Journal Online. Study eligibility criteria: The review encompasses...